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Preheat oven to 350°F (175°C).
In a large bowl, mix ground beef, Ritz crackers, Lipton onion soup mix, eggs, 1/2 cup ketchup, and 1/2 cup barbecue sauce. Combine well and press into a greased 9×13-inch baking dish.
In a pot, cook macaroni noodles according to package instructions. Drain and set aside.
In the same pot, combine milk, condensed cheddar cheese soup, salt, pepper, garlic powder, and onion powder. Cook over medium heat until smooth and heated through.
Stir in cooked macaroni noodles and 2 cups of the shredded cheese blend until melted and combined.
Spread the macaroni and cheese mixture over the meatloaf in the baking dish.
Spread the remaining ketchup and barbecue sauce mixture over the top.
Sprinkle the remaining 2 cups of shredded cheese blend over the casserole.
Bake for 45-55 minutes, or until the meatloaf is cooked through and the cheese is melted and bubbly.
Let cool for a few minutes before serving.
Servings: 6-8